Pro-Calcifying Role of Enzymatically Modified LDL (eLDL) in Aortic Valve Sclerosis via Induction of IL-6 and IL-33

One of the contributors to atherogenesis is enzymatically modified LDL (eLDL). eLDL was detected in all stages aortic valve sclerosis and demonstrated trigger activation p38 mitogen-activated protein kinase (p38 MAPK), which has been identified as a pro-inflammatory atherosclerosis. In this study, we investigated influence on IL-6 IL-33 induction, also impact calcification stenosis (AS). upregulated phosphate-induced valvular interstitial cells (VICs)/myofibroblasts isolated from diseased valves, by alizarin red staining. Functional studies MAPK well an altered gene expression osteogenic genes known be involved vascular calcification. parallel with MAPK, induced upregulation cytokines IL-33. The results suggest pro-calcifying role AS via induction